| Dates of events specific to North Carolina are marked with * and are in bold. |
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| February 1 |
Japanese forces begin evacuating Guadalcanal. |
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February 14–25 |
German and American forces fight the Battle of Kasserine Pass in North Africa. |
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*May 17 |
Asheville native Robert K. Morgan pilots the B-17 Memphis Belle on her twenty-fifth bombing run at the seaport of Wilhelmshaven in Germany. The bomber is the first to complete twenty-five combat missions, and it does so without losing a man. |
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July 9–10 |
Allied forces land on Sicily. |
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July 25–26 |
Italian Prime Minister Benito Mussolini and the Fascist Party are overthrown. |
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September 9 |
Allied forces land on the beaches at Salerno and Taranto, Italy. |
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October 1 |
Allied forces occupy Naples, Italy. |
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*November 2 |
For heroic action on this day during a bombing raid against Japanese shipping near Rabaul, New Britain, Major Raymond H. Wilkins, Army Air Corps, a native of Columbia, Tyrell County, later receives the Medal of Honor posthumously. |
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November 20 |
The U.S. Marines land on Tarawa in the Gilbert Islands. |
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November 28 |
President Franklin Roosevelt, Prime Minister Winston Churchill, and Premier Joseph Stalin meet in Tehran, Iran. |